Can I trust CLEM?

This is the most important question averyone should ask before deciding whether to use a model and goes to the very nature of using someone else's representation of a complex system with potentially limited engagement with those who developed the model. Holzworth et al (2021) in their MODSIM 2021 presentation (see abstract and presentation) suggest the answer to the question posed as the tile of this section is definitely not to trust any model, even one you are very familiar with, and assume all results are suspect until proven otherwise. We recommend you approach any model use with a healthy, sceptical attitude as this will benefit your understanding of the system, the model, and accepting the predictions. Trust in a model will arise from considering the questions outlined by Holzworth et al (2021) and we will address these from a CLEM development perspective to help answer the question of whether this model is suitable for you. We also realise there can be some strong sales pitches for the use of commercial models or models that need to prove uptake to maintain funding. In this section we believe an open and honest approach is the best to help answer this critical question.

 

See next section - Using CLEM